Lean muscle mass increases resistance to Alzheimer's disease: Study
July 12, 2025
  • Read Ecopy
  • Circulation
  • Advertise
  • Careers
  • About Us
  • Contact Us
Organiser
  • ‌
  • Bharat
    • Assam
    • Bihar
    • Chhattisgarh
    • Jharkhand
    • Maharashtra
    • View All States
  • World
    • Asia
    • Europe
    • North America
    • South America
    • Africa
    • Australia
    • Global Commons
  • Editorial
  • International
  • Opinion
  • Op Sindoor
  • More
    • Analysis
    • Sports
    • Defence
    • RSS in News
    • Politics
    • Business
    • Economy
    • Culture
    • Special Report
    • Sci & Tech
    • Entertainment
    • G20
    • Azadi Ka Amrit Mahotsav
    • Vocal4Local
    • Web Stories
    • Education
    • Employment
    • Books
    • Interviews
    • Travel
    • Law
    • Health
    • Obituary
    • Podcast
MAGAZINE
  • ‌
  • Bharat
    • Assam
    • Bihar
    • Chhattisgarh
    • Jharkhand
    • Maharashtra
    • View All States
  • World
    • Asia
    • Europe
    • North America
    • South America
    • Africa
    • Australia
    • Global Commons
  • Editorial
  • International
  • Opinion
  • Op Sindoor
  • More
    • Analysis
    • Sports
    • Defence
    • RSS in News
    • Politics
    • Business
    • Economy
    • Culture
    • Special Report
    • Sci & Tech
    • Entertainment
    • G20
    • Azadi Ka Amrit Mahotsav
    • Vocal4Local
    • Web Stories
    • Education
    • Employment
    • Books
    • Interviews
    • Travel
    • Law
    • Health
    • Obituary
    • Podcast
Organiser
  • Home
  • Bharat
  • World
  • Operation Sindoor
  • Editorial
  • Analysis
  • Opinion
  • Culture
  • Defence
  • International Edition
  • RSS in News
  • Magazine
  • Read Ecopy
Home World

Lean muscle mass increases resistance to Alzheimer’s disease: Study

Lean mass was also associated with better performance on cognitive tasks, but this association didn't explain the protective effect of lean mass on Alzheimer's disease risk

by WEB DESK
Jul 1, 2023, 11:00 pm IST
in World, Health
FacebookTwitterWhatsAppTelegramEmail

Researchers discovered that having a lot of lean muscle may prevent Alzheimer’s. The underlying molecular mechanisms, as well as the consequences for clinical and public health, still require further study.

This study was published in the journal, BMJ Medicine. Numerous studies have found a link between obesity and an increased chance of developing Alzheimer’s disease, which may be explained by the increased inflammation, insulin resistance, and levels of the protein amyloid in adipose tissue that are hazardous to brain health that are brought on by obesity.

Lower levels of lean muscle have also been linked to an increased risk of the disease, though it’s unclear whether this occurs before or after a diagnosis.

To find out, the researchers employed Mendelian randomisation, a technique that employs genetic variants as proxies for a specific risk factor–in this case, lean muscle–to obtain genetic evidence in support of a specific outcome–in this case, Alzheimer’s disease risk.

Bioimpedance–an electric current that flows at different rates through the body depending on its composition–was used to estimate lean muscle and fat tissue in the arms and legs, the results of which were adjusted for age, sex, and genetic ancestry.

Some 584 genetic variants were associated with lean muscle mass; none was located in the APOE gene region that is associated with vulnerability to Alzheimer’s disease. These genetic variants combined explained 10 per cent of the difference in lean muscle mass in the arms and legs of the study participants.

On average, higher (genetically proxied) lean muscle mass was associated with a modest, but statistically robust, reduction in Alzheimer’s disease risk. This finding was replicated in the further sample of 7329 people with, and 252,879 people without, Alzheimer’s disease, using different measures of lean muscle mass–trunk and whole body.

Lean mass was also associated with better performance on cognitive tasks, but this association didn’t explain the protective effect of lean mass on Alzheimer’s disease risk.

Nor was body fat, adjusted for lean mass, associated with the risk of Alzheimer’s disease, but it was associated with poorer cognitive task performance.

“These analyses provide new evidence supporting a cause-and-effect relation between lean mass and risk of Alzheimer’s disease,” said the researchers.

The findings also “refute a large effect of fat mass on the risk of Alzheimer’s disease and highlight the importance of distinguishing between lean mass and fat mass when investigating the effect of adiposity measures on health outcomes,” they added.

But they caution, “Our findings need to be replicated with independent lines of complementary evidence before informing public health or clinical practice.

Also, more work is needed to determine the cut-off values for age and degree of pathology of Alzheimer’s disease after which modifications of lean mass might no longer reduce the risk.”

Nor is it clear whether increasing lean mass could reverse the pathology of Alzheimer’s disease in patients with preclinical disease or mild cognitive impairment, they added.

But they conclude that if future studies back their findings, “public health efforts to shift the population distribution of lean mass, potentially through campaigns to promote exercise and physical activity, might reduce the population burden of Alzheimer’s disease.”

(with inputs ANI)

Topics: HealthAlzheimer's Diseasepublic healthLean muscle massAlzheimerAlzheimer's disease risk
Share1TweetSendShareSend
✮ Subscribe Organiser YouTube Channel. ✮
✮ Join Organiser's WhatsApp channel for Nationalist views beyond the news. ✮
Previous News

Diet tracking is essential for effective weight loss: Study

Next News

Education: Holistic Approach to Medicine

Related News

Low to glow: Finding balance across life’s spectrum

Gujarat Govt launches ‘Swasthya Gujarat, Medasvita Mukt Gujarat’ campaign to promote obesity-free, healthy living

Current antivirals may be less effective against severe infection caused by bird flu virus in cows’ milk: Study

Representative Image

Consumption of ultraprocessed foods linked to rising premature deaths: Study

Odisha leads Immunisation drive: New IEC materials launched to eliminate measles and rubella by 2026

Ayushman Bharat Day: Gujarat’s major success, 70 per cent citizens registered with Ayushman Bharat Digital Mission

Load More

Comments

The comments posted here/below/in the given space are not on behalf of Organiser. The person posting the comment will be in sole ownership of its responsibility. According to the central government's IT rules, obscene or offensive statement made against a person, religion, community or nation is a punishable offense, and legal action would be taken against people who indulge in such activities.

Latest News

Surrendered Maoists with officials in Narayanpur (ANI photo)

Chhattisgarh: Maoists surrender continues in Bastar as 22 more announced their return to mainstream in Narayanpur

Chhatrapati Shivaji Maharaj

Swarajya Symbols Immortalised: 12 forts of Chhatrapati Shivaji Maharaj added in UNESCO world heritage list

Air India Crash: Preliminary Report Reveals Mysterious Engine Shutdown

Air India Crash: Report finds no evidence of sabotage, focus on mysterious engine shutdown — All you need to know

Representative image

Ahmedabad Air India Crash: Fuel control switch error caused engine failure, says AAIB preliminary investigation report

Representative Image

UGC Anti-Ragging Guidelines: Strict punishments to ensure safe and inclusive campuses

Digital India Foundation flags security threat over Pakistan bid to join global AI Alliance Network (AIANET)

Digital India Foundation flags security threat over Pakistan bid to join global AI Alliance Network (AIANET)

National Security Adviser Ajit Doval attends the 62nd Convocation of IIT Madras

Tamil Nadu: Ajit Doval rips into foreign media over Operation Sindoor narrative

Andhra Pradesh: Kamalananda Bharati Swamiji set to commence padayatra to strengthen dharmic and temple centric society

Shubhranshu Singh joins Inaugural Board of Effie LIONS Foundation, to represent India and South Asia

Lieutenant Governor Manoj Sinha

J&K: LG Manoj Sinha lashes out at those spreading false, misleading narratives similar to that of terror organisations

  • Privacy
  • Terms
  • Cookie Policy
  • Refund and Cancellation
  • Delivery and Shipping

© Bharat Prakashan (Delhi) Limited.
Tech-enabled by Ananthapuri Technologies

  • Home
  • Search Organiser
  • Bharat
    • Assam
    • Bihar
    • Chhattisgarh
    • Jharkhand
    • Maharashtra
    • View All States
  • World
    • Asia
    • Africa
    • North America
    • South America
    • Europe
    • Australia
    • Global Commons
  • Editorial
  • Operation Sindoor
  • Opinion
  • Analysis
  • Defence
  • Culture
  • Sports
  • Business
  • RSS in News
  • Entertainment
  • More ..
    • Sci & Tech
    • Vocal4Local
    • Special Report
    • Education
    • Employment
    • Books
    • Interviews
    • Travel
    • Health
    • Politics
    • Law
    • Economy
    • Obituary
    • Podcast
  • Subscribe Magazine
  • Read Ecopy
  • Advertise
  • Circulation
  • Careers
  • About Us
  • Contact Us
  • Policies & Terms
    • Privacy Policy
    • Cookie Policy
    • Refund and Cancellation
    • Terms of Use

© Bharat Prakashan (Delhi) Limited.
Tech-enabled by Ananthapuri Technologies