Scientists discover a new way to detect early colon cancer
Monday, February 6, 2023
  • Circulation
  • Advertise
  • About Us
  • Contact Us
Organiser
  • ‌
  • Bharat
  • World
  • G20
  • Editorial
  • Analysis
  • Opinion
  • Sports
  • More
    • Defence
    • RSS in News
    • Azadi Ka Amrit Mahotsav
    • My States
    • Vocal4Local
    • Business
    • Special Report
    • Culture
    • Sci & Tech
    • Entertainment
    • Education
    • Books
    • Interviews
    • Travel
    • Health
    • Obituary
SUBSCRIBE
No Result
View All Result
  • ‌
  • Bharat
  • World
  • G20
  • Editorial
  • Analysis
  • Opinion
  • Sports
  • More
    • Defence
    • RSS in News
    • Azadi Ka Amrit Mahotsav
    • My States
    • Vocal4Local
    • Business
    • Special Report
    • Culture
    • Sci & Tech
    • Entertainment
    • Education
    • Books
    • Interviews
    • Travel
    • Health
    • Obituary
No Result
View All Result
Organiser
No Result
View All Result
  • Home
  • Bharat
  • World
  • G20
  • Editorial
  • Opinion
  • Analysis
  • Culture
  • Defence
  • RSS in News
  • My States
  • Vocal4Local
  • Subscribe
Home Bharat

Scientists discover a new way to detect early colon cancer

WEB DESK by WEB DESK
Jul 31, 2021, 08:50 am IST
in Bharat
Share on FacebookShare on TwitterTelegramEmail

 

The new study has discovered that six micro RNAs get upregulated in colon cancer cells and that the levels of these were controlled by a master regulator protein named CDX2.

 

New Delhi: Colon cancer is one of the most common types of cancer–both in India and worldwide. According to the Indian Council of Medical Research (ICMR), it is the third most common cancer in men (6, 63,000 cases in 2014, 10.0% of all cancer cases) and the second most common in women (5, 71,000 cases in 2014, 9.4% of all cancer cases).

 

Presently, colon cancer gets detected at very late stages. There are two techniques to detect it; either CT colonography and colonoscopy or immunohistochemistry. While CT colonography involves low dose radiation, colonoscopy is an invasive process, whereas immunohistochemistry can be subjective and sometimes not reproducible.

 

A new collaborative study involving four institutes in India and one in France, led by Dr Sagar Sengupta at the National Institute of Immunology (NII), has discovered a new way to identify the disease even at Stage I, the earliest stage.

 

Dr Sengupta’s laboratory works on micro RNAs, which are small single-stranded non-coding RNA molecules, silence the expression of many proteins. The micro RNAs are known to bind to the messenger RNA molecules that code for the proteins and thereby either inactivate or destroy them.

 

The new study has discovered that six micro RNAs get upregulated in colon cancer cells and that the levels of these were controlled by a master regulator protein named CDX2.

 

Importantly, the upregulated micro RNAs, named `DNA damage sensitive micro RNA’s or `DDSM’s, were found to target a group of cellular proteins essential to maintain the pristine nature of genetic material within each cell of the body. Experiments involving laboratory mice confirmed that the cells have a greater tendency to form cancer if there is overexpression of these micro RNAs and consequent loss of these genome stabilizers.

 

The researchers have tested their findings on publicly available datasets in The Cancer Genome Atlas (TCGA) and in a cohort of colon cancer patients who had come to All India Institute of Medical Sciences (AIIMS), New Delhi, for treatment. Analysis was done with the available data of over 410 patients and the biopsy materials of 54 patients from AIIMS, New Delhi.

 

They found that the DDSMs were upregulated even in Stage I colon cancer tissues. The upregulation persisted up to the final Stage IV colon cancer. More importantly, increased expression of the DDSMs in cancer patients decreased the probability of their survival.

 

Speaking to India Science Wire, Dr Sengupta said, “We believe that the identified DDSMs can serve as an invaluable biomarker for colon cancer early detection process. We now have to determine whether the DDSMs can also be detected in patient blood samples. If that is possible, it would make colon cancer detection as simple as the detection of blood sugar in diabetic patients.”

 

Apart from NII and AIIMS, New Delhi, Regional Centre for Biotechnology, Faridabad, St. John’s Research Hospital, Bengaluru and the University of Strasbourg, France contributed to this study. A report on the work has been published in the Journal of Cell Science.

 

Courtesy: India Science Wire

 

ShareTweetSendShareSend
Previous News

New device to help reduce frequent charging of wireless electronic gadgets

Next News

Mizoram police book Assam CM Himanta, Assam police summons Mizo MP & pastes notice at Delhi residence

Related News

“No salary, no Hygienic water” : Doctors at Delhi’s Rajan Babu and Hindu Rao hospitals to go on strike from Feb 6

“No salary, no Hygienic water” : Doctors at Delhi’s Rajan Babu and Hindu Rao hospitals to go on strike from Feb 6

Organiser e-copy – 12 February 2023

Organiser e-copy – 12 February 2023

Chhattisgarh: BJP leader hacked to death by Maoist in Bijapur’s Usur

Chhattisgarh: BJP leader hacked to death by Maoist in Bijapur’s Usur

PM Modi interacts with participants in Jaipur Mahakhel

PM Modi interacts with participants in Jaipur Mahakhel

Budget 2023: Laying foundation of future Bharat

Budget 2023: Laying foundation of future Bharat

Budget 2023: Focus on ‘Amrit Kaal ‘and Green Growth

Budget 2023: Focus on ‘Amrit Kaal ‘and Green Growth

Comments

The comments posted here/below/in the given space are not on behalf of Organiser. The person posting the comment will be in sole ownership of its responsibility. According to the central government's IT rules, obscene or offensive statement made against a person, religion, community or nation is a punishable offense, and legal action would be taken against people who indulge in such activities.

Latest News

“No salary, no Hygienic water” : Doctors at Delhi’s Rajan Babu and Hindu Rao hospitals to go on strike from Feb 6

“No salary, no Hygienic water” : Doctors at Delhi’s Rajan Babu and Hindu Rao hospitals to go on strike from Feb 6

Chhattisgarh: BJP leader hacked to death by Maoist in Bijapur’s Usur

Chhattisgarh: BJP leader hacked to death by Maoist in Bijapur’s Usur

PM Modi interacts with participants in Jaipur Mahakhel

PM Modi interacts with participants in Jaipur Mahakhel

Budget 2023: Laying foundation of future Bharat

Budget 2023: Laying foundation of future Bharat

Budget 2023: Focus on ‘Amrit Kaal ‘and Green Growth

Budget 2023: Focus on ‘Amrit Kaal ‘and Green Growth

Band, baaja, bulldozer: Groom arrives at his wedding atop a JCB in Gujarat’s Navsari

Band, baaja, bulldozer: Groom arrives at his wedding atop a JCB in Gujarat’s Navsari

BBC documentary on PM Modi: A conspiracy by external adversaries

BBC documentary on PM Modi: A conspiracy by external adversaries

Former Pak President and LeT “biggest supporter” Pervez Musharraf died in Dubai

Former Pak President and LeT “biggest supporter” Pervez Musharraf died in Dubai

President appoints five new judges to the Supreme Court

President appoints five new judges to the Supreme Court

Wanted Maoist held in Aurangabad; security forces unearthed Maoist dump in Odisha’s Kalahandi

Wanted Maoist held in Aurangabad; security forces unearthed Maoist dump in Odisha’s Kalahandi

  • Privacy
  • Terms
  • Cookie Policy
  • Refund and Cancellation
  • Delivery and Shipping

© Bharat Prakashan (Delhi) Limited.
Tech-enabled by Ananthapuri Technologies

No Result
View All Result
  • Home
  • Bharat
  • World
  • Editorial
  • Analysis
  • Opinion
  • Defence
  • Culture
  • Sports
  • Business
  • RSS in News
  • My States
  • Vocal4Local
  • Special Report
  • Sci & Tech
  • Entertainment
  • Education
  • Books
  • Interviews
  • Travel
  • Health
  • Obituary
  • Subscribe
  • Advertise
  • Circulation
  • About Us
  • Contact Us
  • Privacy Policy
  • Cookie Policy
  • Terms of Use
  • Refund and Cancellation

© Bharat Prakashan (Delhi) Limited.
Tech-enabled by Ananthapuri Technologies