New Delhi: Scientists created a new method for diabetic patients to heal their wounds quickly.
Diabetes is a major health challenge for India, showing a trend of increasing prevalence over the years. It is a chronic disease, and over time, uncontrolled diabetes can cause serious damage to many systems in the body, especially the blood vessels and nerves.
In individuals with diabetes, wounds take longer to heal. A large proportion of extremity amputations result from diabetes-induced impairment of wound repair. Timely healing of wounds is therefore pivotal to prevent such extreme consequences. A team of Indian researchers has devised a way to help this happen.
A type of blood cells, called peripheral blood (PB) or bone marrow-derived endothelial progenitor cells (EPCs), contributes to the formation of blood vessels and thus helps in wound healing. However, in people with diabetes, these cells' ability to home in on the wound site is hindered. It adversely influences the healing.
If EPC cells from non-diabetics can be transplanted onto wounds in diabetic individuals, it could enhance blood vessel formation. It helps wounds to heal faster. But, so far, there is no simple method to grow these cells outside the body and deliver them to the wound site. Researchers have been investigating different means to solve the problem. These include biocompatible scaffolds use or matrices that support the growth of cells to deliver the cells at the site of the wound. Most of the matrices created and tested experimentally, however, have had limitations or drawbacks.
A team of scientists led by Dr. Vaijayanti Kale, a former scientist of the Department of Biotechnology’s Pune-based National Centre for Cell Science (DBT-NCCS), and Prof. Jayesh Bellare of the Department of Chemical Engineering at IIT-Bombay has come up with a solution that could break the impasse.
Blending their cell biology and chemical engineering expertise, they fabricated a nanofiber matrix from polycaprolactone (PC) and gelatin (G) using a new method. This matrix showed some very good properties, including its ability to promote the growth of EPCs.
They tested its efficacy as a therapeutic tool to facilitate diabetic wound healing in a standard laboratory animal model for diabetes, using ethically approved experimental protocols. These investigations yielded promising outcomes, and the studies were reported in the international scientific journal, PLOS ONE. In this article, the team proposed that their novel system can serve as a one-step combined growth and delivery system for direct application on skin wounds, including those in Diabetics. Indian Patent Office has also recently granted a patent based on the research work. “Given its double advantage of the ease of handling along with good support for EPC growth, this matrix promises to hold the potential to be used therapeutically in human patients,” the scientists said.
Courtesy: India Science Wire