Dr Abhay Jere

Large biting spiders have sparked panic in remote northeast India, but health authorities fear primitive treatment of the bites’ painful swelling may be more dangerous than the spiders themselves.
Two people died in Tinsukia district after witch doctors used razor blades to drain the wounds. It’s not known if the victims died from spider poison or from the attempted treatment. Local Magistrate Kishore Thakuria said the victims were cremated before autopsies could be done.
Another seven bite victims have been treated with antibiotics against infection after they also tried themselves to drain their wounds, said Dr Anil Phapowali at the local Sadiya town hospital.
The hairy spiders were noticed about a month ago across Tinsukia district’s grassy plains and dense jungle forests north of the Brahmaputra River.
Ecologist LR Saikia at Assam’s Dibrugarh University said it may be a previously unknown species of tarantula. The spiders are roughly the size of a person’s thumb.
“It looks like a new species. We haven’t been able to identify it,” he said. Officials cannot use anti-venom in treating bite victims until the species is identified.
Meanwhile, villagers are keeping lamps on at night and standing guard against spiders entering their mud-and-thatch huts. There are about 100,000 villagers, mostly poor rice farmers, living in the area cut off from roads by the river.
Officials say the spiders are now also showing up south of the Brahmaputra.
(Source: CBC news)?

How infectious disease may have shaped human origins?

Inactivation of two genes may have allowed escape from bacterial pathogens, researchers say. Roughly 100,000 years ago, human evolution reached a mysterious bottleneck: Our ancestors had been reduced to perhaps five to ten thousand individuals living in Africa. In time, “behaviorally modern” humans would emerge from this population, expanding dramatically in both number and range, and replacing all other co-existing evolutionary cousins, such as the Neanderthals.
The cause of the bottleneck remains unsolved, with proposed answers ranging from gene mutations to cultural developments like language to climate-altering events, among them a massive volcanic eruption. Add another possible factor: infectious disease.
Escherichia coli bacteria, like these in a false-colour scanning electron micrograph by Thomas Deerinck at UC San Diego’s National Center for Microscopy and Imaging Research, cause a variety of often life-threatening conditions, particularly among the young. Varki and colleagues suggest a genetic change 100,000 or so years ago conferred improved protection from these microbes, and likely altered human evolutionary development. 
In a paper published in June 4, 2012 online Early Edition of the Proceedings of the National Academy of Sciences, an international team of researchers, led by scientists at the University of California, San Diego School of Medicine, suggest that inactivation of two specific genes related to the immune system may have conferred selected ancestors of modern humans with improved protection from some pathogenic bacterial strains, such as Escherichia coli K1 and Group B Streptococci, the leading causes of sepsis and meningitis in human fetuses, newborns and infants.  
“In a small, restricted population, a single mutation can have a big effect, a rare allele can get to high frequency,” said senior author AjitVarki, MD, professor of medicine and cellular and molecular medicine and co-director of the Center for Academic Research and Training in Anthropogeny at UC San Diego. “We’ve found two genes that are non-functional in humans, but not in related primates, which could have been targets for bacterial pathogens particularly lethal to newborns and infants. Killing the very young can have a major impact upon reproductive fitness. Species survival can then depend upon either resisting the pathogen or on eliminating the target proteins it uses to gain the upper hand.”
In this case, Varki, who is also director of the UC San Diego Glycobiology Research and Training Center, and colleagues in the United States, Japan and Italy, propose that the latter occurred. Specifically, they point to inactivation of two sialic acid-recognised signaling receptors (siglecs) that modulate immune responses and are part of a larger family of genes believed to have been very active in human evolution. 
Working with Victor Nizet, MD, professor of pediatrics and pharmacy, Varki’s group had previously shown that some pathogens can exploit siglecs to alter the host immune responses in favour of the microbe. In the latest study, the scientists found that the gene for Siglec-13 was no longer part of the modern human genome, though it remains intact and functional in chimpanzees, our closest evolutionary cousins. The other siglec gene – for Siglec-17 – was still expressed in humans, but it had been slightly tweaked to make a short, inactive protein of no use to invasive pathogens.
“Genome sequencing can provide powerful insights into how organisms evolve, including humans,” said co-author Eric D Green, MD, PhD, director of the National Human Genome Research Institute at the National Institutes of Health.
In a novel experiment, the scientists “resurrected” these “molecular fossils” and found that the   proteins were recognised by current pathogenic strains of E Coli and Group B Streptococci. “The modern bugs can still bind and could potentially have altered immune reactions,” Varki said.
Though it is impossible to discern exactly what happened during evolution, the investigators studied molecular signatures surrounding these genes to hypothesise that predecessors of modern humans grappled with a massive pathogenic menace between 100,000 and 200,000 years ago. This presumed “selective sweep” would have devastated their numbers. Only individuals with certain gene mutations survived – the tiny, emergent population of anatomically modern humans that would result in everyone alive today possessing a non-functional Siglec-17 gene and a missing Siglec-13 gene.
Varki said it’s probable that humanity’s evolutionary bottleneck was the complex result of multiple, interacting factors. “Speciation (the process of evolving new species from existing ones) is driven by many things,” he said. “We think infectious agents are one of them.”
(Source: University of California, San Diego Health Sciences)?